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Description:These cells have also been assigned a role in tumour angiogenesis and treatment resistance, and upon intercranial transplantation onto immunocompromised mice can successfully seed new tumours [ 10 — 15 ]. Abstract Glioblastoma remains among the most aggressive of all human and canine malignancies, displaying high mortality rates and limited treatment options. The size and structure of the dog's brain, histopathology and molecular characteristics of canine GBM, as well as the presence of the intact immune system, all support canine brain tumours as naturally occurring models of human glioma [ 5 , 7 ]. To date EGFR-targeted interventions alone have been largely ineffective.

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